A few days later, after her return to her home in Aba, eastern region of Nigeria, she was set to address her fellow women having being acknowledged as a female backbone of the National Council of Nigeria and the Cameroons (NCNC), a political party set at the time to help women participate in politics, which was headquartered in the eastern Nigeria. Making her way into the converging hall, Margaret was greeted by a huge crowd of women who came to receive her.
Margaret Ekpo, after exchanging some civilities with them, adjoined the women to stay motivated; and immediately she dived into political campaign, asking them to rise against any opposition at the upcoming poll.
Famous for her articulate speech, Margaret was seen as one who never bored off her audience. With so much things to say as to express her support for women freedom, she was always in high spirit.
On 17th November 1949, there arose a labour disagreement at the British-owned Enugu Colliery which had coal mines in various places like udi, Iva Valley, and Obwetti over unduly dismissals of workers, poor working conditions and wage slashes.
Acknowledging Margaret Ekpo for her Strong role in Enugu strike killing and advocacy for women rights in Nigeria 1959 would be a national honour for every woman in Nigeria
Following the killings at Enugu Colliery the miners joined forces to protest, shops and market women all came out with their friends and neighbours, yet this resulted to the killing of 20 miners and one passerby .
The Britain-led government, a few months afterwards, issued an enquiry into the killing, and even were inviting members of the public to come provide evidence at the Enugu Commission of enquiry.
Raging in hot anger and disappointment, Mrs Margaret at the women conference said that she would go into the first house in Aba Division to shoot any white woman she could find, if any black woman has been injured in Enugu
In Enugu the incident had taken place against the creation of new political parties, generally increasing antagonization towards the Britain-led government.